To illustrate the power and flexibility of the VCCTL system we have chosen three case studies: 1) Replacement of "Coarse" Cement Particles by Limestone Fillers - Hydration and Strength Development (Bentz and Conway, 2001), 2) Multi-Scale Modeling of the Influence of Condensed Silica Fume Additions on the Diffusivities of Cement Pastes and Concretes (Bentz and others, 2000; Bentz, 2000), and 3) Influence of Cement Particle Size Distribution on Properties (Bentz and Haecker, 1999; Bentz and others, 2001). These examples, as sited below, demonstrate the ability to rapidly explore the multiparameter "material design space" to determine the likely desirability of untried formulations.