The NIST 3-D microstructural model has been used successfully to predict the adiabatic temperature rise of a variety of concrete mixtures. Once the model was supplied with the proper kinetics constants, activation energies, and reaction product (e.g., pozzolanic C-S-H) stoichiometries, the agreement between model and experimental temperature rise vs. time curves was quite reasonable for all of the different mixture proportions examined. In addition to the temperature rise prediction, the model also provided estimates of the ultimate achievable degree of hydration for curing under saturated or sealed conditions, as well as the proportion of the silica fume which will react for a given set of mixture proportions. Currently, the model cannot predict the induction period, which limits its application in predicting early age concrete strength development. On the other hand, the prediction of hydration heat, which certainly influences the propensity for cracking of a concrete structure, can be accurately simulated, with any mixture produced with an already characterized (heat capacities, kinetic constants, etc.) set of constituents.